美國 SiELC公司主要供應新型的小分子分離技術并提供相應的色譜柱產品。
SiELC公司推出的色譜柱采用的新型固定相結合了疏水特性和離子交換雙重作用，專門為混合模式分離設計。
Primesep®色譜柱能夠在不同分離模式下，只通過流動相的選擇，成功分離出極大范圍的化合物。
Promix 色譜柱則為蛋白質與縮氨酸的有效分離提供了一種新的選擇，采用新型固定相能得到空前的選擇性與峰容量。
通過這種混合模式分離的蛋白質類的峰容量要比單獨模式分離的峰容量高得多。
SiELC公司最新推出的Obelisc高效液相色譜柱采用最新LiSC（Liquid Separation Cell technology）技術，是LiSC技術的最先例商用型色譜柱。
該品牌共分兩種類型，Obelisc R和Obelisc N，可以運用多種分離機制，分別用來分離極性和非極性化合物。
–Primesep
Primesep stationary phases offer unprecedented selectivity in the separation of a broad array of chemical compounds and in multiple applications.
A wide range of HPLC columns with id’s from 0.5 mm to 22 mm are available.
Corresponding Primesep guard columns are available with all stationary phases and do not require holders.
SIELC offers a method development service which is available for all customers.
Ask about our special custom LC-phases tailored for specific separations.
–Newcrom
A column with a new outer design. This column and corresponding adapter entirely eliminate the need for any high-pressure fittings or tubing
as well as minimizing all possible dead volumes. Furthermore, if a leak ever occurs in the high-pressure column inlet, the mobile phase is
contained within the column adapter (no external leakage). Read more.
–Obelisc
Two complimentary columns, Obelisc R and Obelisc N, based on Liquid Separation Cell ( LiSC ?) technology, offer a new approach to separate
a variety of small molecules. Buffer concentration, buffer pH, and organic modifier concentration are three orthogonal parameters
of the mobile phase that allow adjustment of column properties to separate complex mixtures.
–Cannsep
SIELC has developed a special line of Cannsep columns to resolve most of the compounds attributed to cannabis physiological properties.
Three columns: Cannsep A, Cannsep B, and Cannsep C resolve all the cannabinoids providing different and
significantly orthogonal selectivity.
–Legacy
SIELC has developed the Legacy column, which can be used in many USP Validated methods.
–Promix
Promix is an alternative chromatography technology for efficient resolution of peptides and proteins. The technology is based on a
combination of two interactions – hydrophobic and ionic. This approach is possible due to a new type of separation media: a
chemical combination of hydrophobic and ionic functional groups on a ligand bonded to a silica support.
With this phase, unparalleled selectivity and peak capacity can be achieved. Independent
adjustment of the amount of buffer and organic modifier creates an
infinite number of separation conditions that are suitable
for many types of bio-molecules.
–SHARC?
SHARC? HPLC columns are the latest, innovative columns from SIELC Technologies, the inventors of Primesep®. SHARC?
columns are the first commercially available columns with separation based primarily on hydrogen bonding.
SHARC stands for Specific Hydrogen-bond Adsorption Resolution Column. Hydrogen bonding is
an interaction (attraction) of bound hydrogen atom to the molecules with electronegative
atoms such as oxygen, nitrogen, and fluorine.
–Specialty Columns
There are several million compounds isolated and described in chemical literature. An even greater number of combinations
of these compounds (mixtures) requires analysis by HPLC. SIELC produces custom phases for our customers who
were not able to obtain desirable results with commercially available HPLC phases.
–Solid-Core
SIELC Technologies has developed mixed-mode Columns based on solid-core-porous-shell particles. This separation
media combines the efficiency of solid-core technology with the unique selectivity of Ion-Exchange (IE),
reverse phase (RP), surface chemistry and ion-exchange HILIC surface.
